laboratory mice strains

U.K. regulations are considered amongst the most comprehensive and rigorous in the world. [22][23], Male BALB/c mice are aggressive and will fight other males if housed together. The classical laboratory mouse strains derive from a small, ancestral population of wild founder animals that were selectively bred for traits of interest by mouse fanciers in … [12], Various mutant strains of mice have been created by a number of methods. The Jackson Laboratory [10] In 2011, an estimated 83% of laboratory rodents supplied in the U.S. were C57BL/6 laboratory mice. Scientists have found that the genetic variation in the most widely used strains of laboratory mice is vastly greater than previously thought. Author information: (1)Department of Psychology and Centre for Neuroscience, University of Alberta, Edmonton AB, Canada. Laboratory mice strains - Bewundern Sie unserem Testsieger. [12] compared to an estimated 20,774 in humans. A small selection from the many available strains includes -. The pathogenicity of the murine astrovirus was not known. Hundreds of new papers referencing JAX® Mice strains are published each month. Laboratory mice strains - Bewundern Sie unserem Testsieger. [35] Murine astrovirus was found in nine mice strains, including NSG, NOD-SCID, NSG-3GS, C57BL6-Timp-3−/−, uPA-NOG, B6J, ICR, Bash2, and BALB/C, with various degrees of prevalence. The mice were backcrossed by Boyseto a C57BL/6Boy inbred background to select for SJL antigen type (now referred to as Ptprca or Ly5.1). Laboratory mice have also been used to maintain a number of strains on a long-term basis, and many different types of strain analyses, including genotype analysis, have … Routes of administration of injections in laboratory mice are mainly subcutaneous, intraperitoneal and intravenous. One of the most time-consuming activities in research laboratories is looking up information specific to the species or strain of animal being used. Mice are mammals of the clade (a group consisting of an ancestor and all its descendants) Euarchontoglires, which means they are amongst the closest non-primate relatives of humans along with lagomorphs, treeshrews, and flying lemurs. To complement this published information, we routinely conduct studies to gather physiological data on JAX® Mice strains. C57BL/6 mice have a dark brown, nearly black coat. With inclusions of the newly revised European standards on laboratory animals, this will be the most current, global authority on the care of mice in laboratory research. Mating can be confirmed by the presence of a copulatory plug in the vagina up to 24 hours post-copulation. The different strains are identified with specific letter-digit combinations; for example C57BL/6 and BALB/c. The average litter size is 10–12 during optimum production, but is highly strain-dependent. Compliance with the PHS is required for a research project to receive federal funding. Due to the large number of strains of laboratory mice, it is impractical to comprehensively describe the appearance and behaviour of all of them; however, they are described below for two of the most commonly used strains. and differences (thigmotaxis, stress calls, habituation to acoustic startle, etc.) [7], Newborn males are distinguished from newborn females by noting the greater anogenital distance and larger genital papilla in the male. Debate grows over new mouse models of cancer", "There's more to life than rats and flies", "Unbridle biomedical research from the laboratory cage", "The inescapable problem of lab animal restraint | Garet Lahvis | TEDxMtHood - YouTube", "Male Scent May Compromise Biomedical Research", "Mouse microbes may make scientific studies harder to replicate", "China's Selling Genetically-Modified Mice for $17,000 a Pair", Pictures, movies and applets showing the anatomy of, Michael Purdy: "Researchers add mice to list of creatures that sing in the presence of mates", High-Resolution Brain Maps and Brain Atlases of, Nolthenius's long-tailed climbing mouse (, https://en.wikipedia.org/w/index.php?title=Laboratory_mouse&oldid=996946357, Articles with unsourced statements from December 2018, Creative Commons Attribution-ShareAlike License, Waltzing mice, which walk in a circular pattern due to a mutation adversely affecting their inner, Abnormally large mice, with an inserted rat, Fat mice, prone to obesity due to a carboxypeptidase E deficiency, This page was last edited on 29 December 2020, at 08:37. The first inbred strain of mice was DBA, developed in about 1909 by Dr. C.C. [16], C57BL/6 has several unusual characteristics which make it useful for some research studies but inappropriate for others: It is unusually sensitive to pain and to cold, and analgesic medications are less effective in this strain. The susceptibility of laboratory mice to Borrelia burgdorferi was evaluated for selected genotypes and ages. In contrast, outbred populations are used when identical genotypes are unnecessary or a population with genetic variation is required, and are usually referred to as stocks rather than strains. [4] The mouse has since been used extensively as a model organism and is associated with many important biological discoveries of the 20th and 21st Centuries. Mice are polyestrous and breed year round; ovulation is spontaneous. The suppliers were not identified by name due to ethical reasons. These mice strains showed both similarities (social interaction, novel recognition, FST, TST, spatial memory, Y-maze tasks, etc.) In order to claim a certificate or badge for this MiniCourse, you must go through the Core Content module and take the self-review quiz (scoring at least 70%). While we are not an accredited higher education institution, we offer a variety of education programs — including our non-credit bearing MiniCourses — designed to educate current and future scientists and to provide critical resources, data, tools and services to researchers worldwide. [58], For example, researchers have found that many mice in laboratories are obese from excess food and minimal exercise, which alters their physiology and drug metabolism. Research, recent research has shown that this type of handling laboratory mice more frequently seen in female mice male., bacterial, parasitic, and ICR mice, this is accomplished through.! 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