Her body was like a noodle. I have an eight year old cockapoo, who has been like my third child. While the exact mechanism of action is not known, it is thought that Apoquel works by inhibiting the activity of Janus kinase enzymes, which are important in signal transduction in many cells, including those involved in the allergic response. My 14 year old Boston Terrier.my best friend in the world had been plagued by itching his entire life. However, after about 2 months on the medicine he started urinating in the house. The pills are gone and I am unable to afford another $200+ vet visit plus a larger supply of Aproquel. Cetirizine hydrochloride, also known by its brand name Zyrtec, is a fairly new type of antihistamine that veterinarians have found useful in treating some canine allergies. He takes 16 mg. daily and the scratching has almost stopped. Baytril a huge heavy hitter in antimicrobials, but scant other basic antibiotics on your shelf that could be used as a first line. If youre wondering how I treat my dogs allergies, I focus on diet. Still itching and the straw that broke the camels back was seizures. You can check http://www.orthomolecular.org for more research and info. I dont care what my vet says. For a sonogram and X-rays that showed everything is normal. His nose is cold and his behavior is normal, but we are very worried. Denise. Am wondering, Kelly, if you ever got any answers? We had to use the Apoquel because he needed surgery for a torn ACL and couldnt use prednisone. I will search for more ideas. I was assured this drug was safe. The combination of these drugs can result in undesired side effects for your pet including vomiting and diarrhea. DrugBank Accession Number. Mix all together and freeze in portions and Voila! I have photos of that food really odd changes!!! We all need to do our part to get this drug off the market. Also, the little guy was not scratching. Then my other boy has high liver enzyme. The dosage will depends on your dog's weight. He is aware of the harmful side effects of prescription drugs and is trying to give us healthier alternatives for our loving pets. You have to understand one thingPeatie has a laundry list of ailmentsarthritis (all limbs and back, heart murmur (diagnosed at first vet visit), cataracts (90% blind) and close to 100% deaf. An OTC alternative might be Benadryl for your dog. Avoid synthetic drugs unless there is no other way. I AM STOPPING THIS MED TODAY! However, it is important to speak to your veterinarian about the best treatment plan for your dog. I am aware that in the pharmaceutical world when a medication becomes FDA approved, the company must conduct as post marketing surveillance program to detect any adverse events or idiosyncratic reactions that occur especially when the medication is being utilized in a much large patient population. In fact, right now Apoquel has no drug interactions with any other type of medication, so it can be used along with just about anything. I started looking at this site or blog for answers for the insane paw licking my baby goes through every year around Aug., Sept. I am certain that Apoquel caused this problem. I have three Shih Tzu on Apoquel for three months. I can not believe this is on the market with how many dogs have had issues from it. WBC elevated, slight temperature, abdomen tender to touch and very dehydrated. Another dog required Its nice to see her not so stressed out over scratching and with a beauriful full coat. Blood work showed he was in severe liver failure with liver enzymes and glucose levels very high. See what it can do for your dog here: http://www.thedogsupplement.com. Dogs will also need to be monitored for bone marrow suppression if on Apoquel for the long term. 1 [deleted] 8 yr. ago These medications may cause some risk when taken together. He is nibbling them constantly. I have to admit, I may be the only one in support of Apoquel. Despite providing the vet center with a copy of my letter to Zoetis and their request to have the vet contact them to discuss this AE, as of 9-6-19 the vet has not contacted them. diarrhea, vomiting, and lethargy that resolved spontaneously in 90% of cases and did not I had noticed over the past few months he limped or tripped on his feet a few times, but he has hip dysplasia and we thought his hips were getting worse and that was the reason for the decline in his walking and climbing stairs. Our vet is pretty awesome and very in depth with everything and will answer any question we can think of and makes sure we understand everything. Now, just do the rest of the world a favor and drop off the face of it and stop trying to scare people into doing what you want and believing what you think is correct. It works well for mild allergic reactions, such as an insect bite or sting. After reading these post Im convinced its the Apoquel. He spent two days in the hospital getting IV fluids, pain medicine and nausea medication. Its been 2yrs of no Atopica. Antihistamines can also be used to treat anxiety, and to calm patients before general anesthesia and surgery, found that 54% of dogs with atopic dermatitis that had been given antihistamines to treat the condition responded favorably, your dog may be displaying signs of anxiety because of discomfort, Hydroxyzine hydrochloride is the most common treatment for pruritus in dogs, Best Dog Food For Seniors With Sensitive Stomachs, Best Dog Food for Small Dogs with Sensitive Stomachs, Hydrogen Peroxide For Dogs Vomiting, Ears, Wounds, Other Issues. I noticed she had to see alot, but only thought she was marking her spots. She was given a shot of something at the vet to help with itching. But I dont know if 30 days is enough. The next 24 hours passed and I saw his behavior change, He finally went to his water bowl, then asked to go out and potty. My 10 year old Maltese 10 pound has had intermittent allergy problems his entire life. The most common side effect is drowsiness. The colostrum dose for dogs with allergies varies based on the company; I advise giving of the human dose per 20lbs daily. Ive had my terrier mix dog on Apoquel for a year and a half. In fact, antihistamines are quite often used to treat skin allergies in dogs. My son just lost his beautiful 3 year old Dalmatian to the drug. Customer: My dog has been on Cytopoint for 2 years and I can't get her in for almost 10 days and she's miserable JA: I'll do all I can to help. Hydroxyzine HCI tablets are available by veterinary prescription for dogs. The vet gave my 16 month old Yellow Lab Apoquel for her allergy skin issues yesterday. Can you give a dog Apoquel and Benadryl at the same time? He recently peed a huge puddle in the kitchen and the living room when he is the best out of my three dogs about holding it or telling me has to go. After autopsy Im told he had tumor like growths in his chest. I think it could be a very dangerous drug. It was under the skin, wide but flat so it didnt show under his hair and wasnt obvious when patting him. If anyone has experienced this side effect and has any additional information I would greatly appreciate the knowledge. She runs into everything and everyone. The reports of the studies list everything that the animals in the studies had while in the study, but a causative relationship cannot be made, merely an association . My senior Dog, was put on apoquel 2 weeks ago. We tried Benedryl, claritan,and zyrtec, nothing worked except prednisone in combination with antibiotics. The last time I had her back on it she has had severe nausea at night and trembling. She recently started peeing her bed and on the floor. Hi, my sweet grand pup was put on Apoquel about 9 weeks ago for allergies. I bathe her twice a month too. Genestra Vit D drops 800 ui/day. Apoquel is the only thing that has worked. These growths developed quickly within two weeks and caused concern warranting removal and testing. Two of my staffies have been put on these tablets but after reading all these comment Im stopping them. Our friend was aware of the allergy and per her normal vet was doing a process of elimination with his food, treats, shampoo, etc. Vet Dermatol 2013;24:587-597.). She was totally out of it. I wouldnt take our dogs almost considered human to a vet i didnt trust. I paid $10,000 or more over 12 years trying to heal my dogs itching. Like everyone else it helped make her more comfortable at first then increased eating and lethargy. There are a few things youll want to know before giving this to your dog. His food has been changed to a taste of the Wild salmon and gets fish oil and vitamin e supplements without much relief. Two days ago, I woke up in the morning and went to feed by dog and he could not walk or stand. One morning about 5AM she woke me standing up on the bed and she froze and fell off the bed like a statue and had a seizure. Strange about aggression as a side effect could it be she just doesnt feel good on the drug and irritable? Use the best of all forms of proven, safe and effective methods to find underlying causes and correct them. I rescued a red male lab/pit mix who was sick with kennel cough. My dog was prescribed this to help stop the itch for her mysterious skin infection / bacteria ( that the vet could not tell what it was after paying over $500.00). Apoquel may increase the chances of developing serious infections, and may cause existing parasitic skin infestations or pre-existing . In April we reduced her to 1/2 every morning but it was no longer being effective.I raised her dosage back to1 -3.6mg a day and she started having seizures. and said everything is normal, probably will never happen again. Can you give dogs Benadryl and Apoquel together? Her white hair on her lower back turned red from her itching and got worse with bumps all over her lower back. I called the vet but they said she must have eaten something to cause it. Im at the end of the road here in my hopes for Ollie to be healthy. no more for Her, and a new vet , too !! If Cytopoint and Apoquel are going to be effective in a particular dog, they typically begin to work within the first 24 hours but may take a little longer to reach peak efficacy. We even had a needle biopsy done. I knew nothing about Apoquels side effects until I saw their commercial a couple of months ago where it states a lot of bad things that can happen to your pet including making cancer grow MUCH faster. We are devastated. The day I bought the second months prescription at the cost of $105 my dog began having bloody diareah. It makes me sick to my stomach to see so many vets pushing and advertising this. She had a brain tumor. But just a few days later she was falling and pacing and panting. My poodle is masterful at holding it in emergencies when we get home longer than planned. It helps relieve really bad side effects of chemotherapy such as anemia, pain and nausea. I wish I had researched this forum before. She has had none of the issues above. She was tired and started staring off so we took her to vet. 1.7m dogs were tested. Zyrtec, or Cetirizine, is a popular method of itch relief in our canine friends due to how few side effects there are, and the fact that Zyrtec does not cause drowsiness like other allergy medications. But, there are also side effects that you should keep in mind. Who knows what would have happened if we continued another 2 weeks especially wth out dog being a senior. At this point our cost has been $2200. The dose of Apoquel tablets is 0.18-0.27 mg/lb (0.4-0.6 mg/kg). Metronidazole (also known by the brand names Flagyl, Metizol, Protostat, Metrogel) is a strong antibiotic primarily used as an antidiarrheal to treat inflammation of the large intestine. I am a natural leaning person who is not crazy about drugs of any sort but there are times when I think is the only solution. She said some dogs respond better to one drug than the other. Histamines are compounds in the body which are responsible for the symptoms we experience when we are allergic to something. They contacted my vet. I contacted the makers of this pill. She had 10 seizures in 3 months. Heres a handy chart to help you figure out the right dosage for your pup: Mutasim is an author and software engineer from the United States, I and a group of experts made this blog with the aim of answering all the unanswered questions to help as many people as possible. You may stop using medications all together. I still use the same vets but now use a different vet who we use exclusively so she is aware of my boys issues. Took him to the vet today and he has kidney failure. Hamish is very threadbare and I have been loathed to clip him. My 10 years old English Bulldog Sophie has the worst allergies..Digging,scratching,dragging,bleeding etcI chose to try the Apoquel less than w week agoBIG MISTAKE!!!! 2 days into treatment puppy started crying when he was put into his carrier for bedtime. It has been a miracle drug for her giving her so much better quality of life! Bull and Black Mouth Curr Mix. At the beginning, our vet told us to give him the pill twice daily for the first week, and then once a day after that. can respond inappropriately, and may begin attacking the I took him to my vet and he put him on Doxycycline. I would rather give him zyrtec and deal other ways with his allergies. She also acts like she can see something that gets her attention and stares for ages. Thank you for this eye opening site, so important to be informed on the dangers os all meds. Zoetis has made a fortune on this drug, it is time to stop the suffering. By week 7 he was having diarrhea and was put on Metronidazole. Stay away from this POISON. Within a day he had lost his appetite and was less playful than usual. NONE OF THESE SO-CALLED VETS EVEN I should have switched him to the prednisone after his ACL surgery but didnt think about it and didnt know that he had this tumor. frequent bathing, washing feet frequently etc. Of course the cost is skyrocketing and he is scheduled to have a liver Ultrasound today and a liver fine needle aspiration has been mentioned. Ruined 6 months of our lives. Apoquel tablets for dogs comes strengths of 3.6mg, 5.4 mg and 16mg of oclacitinib per tablet. Generally, a 7 to 10-day therapeutic trial will reveal if the treatment is going to work. What do we do to protect our fur babies? Karen. Within the first 12 hours he developed runny poop and lethargy. I weaned her off the Hydroxyzine and started her on the Apoquel. Im conflicted now that I might have caused this. One morning I got up and he was shaking in his cage and couldnt lift his head. Infection after infection after infection lead to Apoquel. Im sure Zoetis doesnt want law suits so Im sure theyve doe their research. Just not for any on this wall including mine. During the initial first 14 day period her itching just vanished BUT I noticed her having one or two weird wobbles, not thinking much of it I continued with the Apoquel. He was a healthy and playful boy and certainly did not act his age!!! We must consider what people are saying. This is where we get our information. Every ingredient in my supplement have been tested on thousands of dogs, with little to no side effects. I have also let my daughter know as she has 2 Doxies on it for itching and allergies as well. The Vitamin C dose is 100mg per 10lbs twice daily. Kudos to the very few who this drug has helped, I will not be taking that gamble. In a study, dogs were treated with Apoquel for more than 2 years. If these sort of dermatologic/parasitic overgrowths occurred in humans from treatment with JK inhibitors, it would certainly prompt the FDA to take action to protect the patient population utilizing these medications from these severe adverse events He continues to take 1 pill each day, although we have . I usually research medications on the internet before taking them and this is the TRAGEDY OF MY LIFE, as I did not do it thoroughly, I trusted the doctor and when I looked it up I only read one first ad that pops up , ad from Zoetis, they only list vomiting, diarrhea and gastrointestinal problems, that right there should have been a Red flag for me, but again, THIS IS THE TRAGEDY OF MY LIFE. 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